Vela Diagnostics présente ses panels de séquençage des gènes du cancer ciblés (60 gènes) et complets (525 gènes) basés sur les NGS

HAMBOURG, Allemagne, 28 mars 2022  /PRNewswire/ — Vela Diagnostics a annoncé aujourd’hui le lancement de ses nouveaux panels de séquençage OncoKey® SL 60 et 525 Plus. Ces panels basés sur les systèmes de séquençage de nouvelle génération (NGS) sont conçus pour détecter les biomarqueurs d’ADN et d’ARN du cancer à partir d’échantillons de tissus fixés au formol et inclus en paraffine (FFPE), pour un maximum de 64 échantillons par cycle de séquençage.

Vela Diagnostics propose deux panels de séquençage des gènes du cancer : le système OncoKey® SL 60 Plus et le système complet OncoKey® SL 525 Plus. Avec seulement 40 ng d’acide nucléique, le panel de séquençage peut détecter les biomarqueurs suivants en un seul test : polymorphisme d’un seul nucléotide (PSN), insertions ou délétions (indel), variations du nombre de copies (copy number variations, CNV), instabilité des microsatellites (microsatellite instability, MSI), fusions, épissage alternatif, virus et bactéries oncogènes, et peut mesurer la charge mutationnelle tumorale (CMT).

Ces panels basés sur les NGS présentent un flux de travail hautement automatisé, de l’échantillon au résultat. Ils peuvent produire des résultats en cinq jours, ne nécessitent que 2,5 heures de travail manuel et assurent une traçabilité élevée des échantillons, de l’extraction automatisée des échantillons au contrôle de la qualité (CQ) des données. VELA® Analytics permet de créer des rapports internes concis, fondés sur des données probantes, qui fournissent aux clients les informations nécessaires pour prendre des décisions éclairées quant aux options de traitement possibles. Par ailleurs, les laboratoires disposant de peu d’échantillons peuvent choisir d’effectuer les tests manuellement.

Le flux de travail des panels OncoKey® SL 60 et 525 Plus repose sur les plateformes de séquençage Illumina. Les panels peuvent donc s’adapter sans problème aux situations actuelles des laboratoires. Associés à des adaptateurs UMI-UDI doubles, à un système de capture par hybridation, à un séquençage par synthèse et à un pipeline bio-informatique validé avec soin, les panels présentent une sensibilité élevée et un profilage complet des variantes, ainsi qu’une couverture de séquençage uniforme.

« Les panels OncoKey® 60 et 525 Plus de VELA sont un formidable progrès dans la médecine de précision pour le cancer, a déclaré le Dr Andreas Goertz, directeur général de la division européenne de Vela Diagnostics. Ces panels sont composés de gènes pertinents d’un point de vue clinique et ont été conçus sur la base de contributions de personnalités influentes dans le domaine de l’oncologie, ainsi que de références à des directives professionnelles, à des essais cliniques et à des bases de données sur le cancer. »

« Vela Diagnostics prévoit de rendre disponibles les panels OncoKey® 60 et 525 Plus au quatrième trimestre 2022 aux États-Unis et en Asie-Pacifique, a ajouté Sam Dajani, PDG et président exécutif de Vela Diagnostics. L’utilisation de ces panels sur le flux de travail automatisé de Vela Diagnostics permettra de réduire les erreurs humaines et de minimiser la contamination croisée des échantillons qui peut être engendrée par un flux de travail manuel. Par ailleurs, nos solutions et services VELA® Analytics peuvent identifier et interpréter les variantes génétiques dans les tumeurs, ce qui permet de fournir rapidement et avec précision des options exploitables aux professionnels de la santé et de la recherche. »

À propos de Vela Diagnostics

Vela Diagnostics est un fournisseur de premier plan de solutions intégrées de diagnostic in vitro, de l’échantillon au résultat. Les solutions de test de VELA utilisent la plateforme automatisée Sentosa®, et offrent la possibilité unique d’utiliser un seul système pour les tests NGS et PCR dans le domaine des maladies infectieuses et de l’oncologie.

Tous les produits Sentosa® énumérés ci-dessus sont de Vela Diagnostics. Pour plus d’informations, consultez le site www.veladx.com. Tous les autres noms de produits, marques déposées et logos sont la propriété de leurs détenteurs respectifs.

Contact pour les médias :

vince.yip@veladx.com

 

 

Vela Diagnostics Launches Focused (60 Genes) and Comprehensive (525 Genes) NGS-Based Pan-Cancer Panels

HAMBURG, Germany, March 28, 2022 /PRNewswire/ — Vela Diagnostics announced today the launch of its new OncoKey® SL 60 and 525 Plus Panels. These next-generation sequencing (NGS)-based panels are intended for detection of DNA and RNA cancer biomarkers from formalin-fixed paraffin-embedded (FFPE) tissue specimens, for up to 64 samples in a single sequencing run.

Vela Diagnostics offers two pan-cancer gene panels: the focused OncoKey® SL 60 Plus Panel, and the comprehensive OncoKey® SL 525 Plus Panel. With just 40 ng of nucleic acid, the panel can detect the following biomarkers in one assay: single nucleotide variations (SNVs), insertions/deletions (INDELs), copy number variations (CNVs), microsatellite instability (MSI), fusions, splice variants, oncogenic viruses and bacteria, as well as measuring the tumor mutation burden (TMB).

These NGS-based panels feature a highly-automated, sample-to-result workflow. They are able to produce results within 5 days, requiring only 2.5 hours of hands-on time, and provide high sample traceability, from automated sample extraction to data quality control (QC). VELA® Analytics can create concise, evidence-based in-house reports that help customers with the information to make timely, informed decisions about possible treatment options. Additionally, laboratories with low sample volumes can choose to perform the assays in a manual workflow.

Crucially, the OncoKey® SL 60 and 525 Plus Panel workflow is wrapped around Illumina sequencing platforms. Thus, the panels can be seamlessly adapted to current lab situations. Combined with dual UMI-UDI adapters, hybrid capture target enrichment, sequencing by synthesis and thoroughly validated bioinformatics pipeline, the panels boast high sensitivity and comprehensive variant profiling, plus sequencing coverage uniformity.

“VELA’s OncoKey® 60 and 525 Plus Panels represent an exciting development in precision medicine for cancer,” said Dr Andreas Goertz, Managing Director of Vela Diagnostics’ European organization. “These panels consist of clinically relevant genes of interest and were designed based on input from key opinion leaders in oncology, as well as references to professional guidelines, curated clinical trial and cancer databases.”

“Vela Diagnostics is planning to launch our OncoKey® 60 and 525 Plus Panels in Q4 2022 in the USA and Asia Pacific,” said Sam Dajani, CEO and Executive Chairman of Vela Diagnostics. “Using these panels on Vela Diagnostics’ automated workflow will reduce human error and minimize sample cross contamination which can be generated by using a manual workflow. In addition, our VELA® Analytics solutions and services can identify and interpret genetic variants in tumors making it possible to provide actionable options for healthcare and research professionals quickly and accurately,” added Mr Dajani.

About Vela Diagnostics

Vela Diagnostics is a leading provider for integrated IVD system solutions, from sample to result. VELA’s test solutions utilize the automated Sentosa® platform, providing the unique ability to leverage one system for NGS and PCR testing in infectious disease and oncology.

All Sentosa® products listed above are by Vela Diagnostics. For more information, visit www.veladx.com. All other product names, trademarks and logos are the property of their respective owners.

Media Contact

vince.yip@veladx.com

Commentary: The Oscars’ very weird night

Published by
The Seattle Times

Did Sunday night’s Academy Awards ceremony achieve its goal, stated earlier this month by academy president David Rubin, to “prioritize the television audience, to increase viewer engagement and keep the show vital, kinetic, and relevant”? Um, be careful what you wish for, Oscar. The 94th annual Oscars, hosted by Wanda Sykes, Regina Hall and Amy Schumer, was a very strange night, to put it mildly. Before things began, it seemed like we’d be talking about “The Power of the Dog” and about the academy’s strange decision to present eight of the categories in a pre-show, not showing them live. Inst… Continue reading “Commentary: The Oscars’ very weird night”

Presales Open for Metahunter: The Metaverse for All

The combination of MMORPG, Sandbox, and open-world concepts opens the door to a new Metaverse.

SINGAPORE, March 28, 2022 /PRNewswire/ — A new dawn is coming to the virtual world in the shape of Metahunter, a platform that is focused on accessibility, education, and opportunity for any and all who want to experience the metaverse. Presales have now begun at https://metahunter.com/.

Metahunter Logo

With over 500 influencers onboarded into the ecosystem, Metahunter is on track to becoming the largest Metaverse space in the world. Metahunter aims to become the Metaverse for all by providing equal opportunity to all regardless of social level, becoming the first of many to make the virtual experience a reality for millions of unserved people worldwide.

Metahunter Influencers Community

Unlike many other projects created in the market, Metahunter isn’t just trying to take advantage of the hype and short-term profits. Instead, Metahunter makes the Metaverse experience accessible to tens of millions of people in the market who don’t currently have the opportunity and knowledge to participate due to high entry costs and other barriers.

Not only does Metahunter provide a beginner-friendly platform, but it also provides a place for newcomers to learn more about play-to-earn gaming and blockchain technology. It gives everyone a chance to get into Metaverse at an affordable price. The new platform will offer those that haven’t been able to participate in play-to-earn gaming a unique first-time opportunity.

Allen Tan Chee Hoe

Founded by Allen Tan Chee Hoe, who previously founded Findwork, a recruitment platform with over 4 million verified and certified users that connects underserved personnel to working opportunities. Currently, Allen leads the Metahunter team of seasoned executives in blockchain, technology, capital markets, marketing, entrepreneurship, gaming, influencers, community builders, and more. The Metahunter team has a background from companies like Facebook Gaming, SuperCell, J.P. Morgan, Renaissance Capital, etc.

Unlike other platforms which rely on bots or other sources to generate traffic, Metahunter will build an organic approach. With a possible outreach of at least 100 million people globally, Metahunter is on track to create the most immersive Metaverse experience.

Metahunter is a “Metaverse for All” where everyone can play, learn, and earn together. Take advantage of this early opportunity, and let’s build the largest Metaverse world together!

Logo – https://mma.prnewswire.com/media/1766819/logo_final_Logo.jpg
Photo – https://mma.prnewswire.com/media/1769461/1.jpg
Photo – https://mma.prnewswire.com/media/1769462/2.jpg

Biden: Putin Comment Was About ‘Moral Outrage’

PENTAGON — U.S. President Joe Biden said Monday that he would make “no apologies” after his recent comment that Russian President Vladimir Putin “cannot remain in power,” stressing he was “expressing moral outrage” and not actually calling for regime change in Moscow.

“People like this shouldn’t be ruling countries, but they do. The fact they do doesn’t mean I can’t express my outrage about it,” Biden told reporters at the White House on Monday.

“I wasn’t articulating a policy change,” he said.

The president’s unscripted remark about Putin, while speaking with Ukrainian refugees and international volunteers in Poland on Saturday, stirred controversy in the United States and caught some allies in Western Europe by surprise.

“The last thing I want to do is engage in a land war or a nuclear war with Russia,” Biden said, while rejecting the idea that his comment could escalate tensions over the war in Ukraine.

Meanwhile, Russian troops have stopped ground advances toward the Ukrainian capital of Kyiv as they appear refocused on regions in eastern Ukraine, according to senior official from the U.S. Department of Defense.

“They clearly are not moving on Kyiv anymore,” said the official, who briefed reporters on background Monday. “What we are seeing is this continued reprioritization on the Donbas.”

Moscow’s latest military shift appears to be an effort to cut off Ukrainian forces in the eastern region, according to the official, adding that the move “could be an attempt by the Russians to gain negotiating leverage” in peace talks with Ukrainian representatives trying to end the war.

Mercenaries

Britain’s Defense Ministry said Monday that a private Russian mercenary company, the Wagner Group, has been deployed to eastern Ukraine.

“They are expected to deploy more than 1,000 mercenaries, including senior leaders of the organization, to undertake combat operations,” the ministry said. It added that the troops were being pulled from Syria and Africa.

The top commander of U.S. military forces in Africa, General Stephen Townsend, told VOA earlier this month that the Wagner Group was trying to recruit its mercenaries in Africa to fight in Ukraine.

Russia has been backing separatists in the Donbas region of eastern Ukraine since at least 2014, when Moscow illegally annexed Ukraine’s Crimean Peninsula.

Ukrainian forces have stopped Russian troops from taking most major cities.

Nearly 5,000 people, including more than 200 children, have been killed in the southern city of Mariupol, which Russia has heavily bombarded since the invasion started last month, according to the mayor’s office.

Mariupol’s mayor on Monday called for evacuation of the remaining 160,000 residents. Ukraine’s deputy prime minister, however, said no humanitarian corridors would open, because of intelligence reports of potential Russian assaults on the routes.

“We’ve seen the Russians announce humanitarian corridors and then promptly shell them, or mortar them, or strike them,” the senior U.S. Defense official said Monday in response to a question from VOA, without speaking to Ukraine’s recent assertions.

Near Kyiv, the large suburb of Irpin has been liberated from Russian forces, according to Mayor Alexander Markushin.

“We understand that our city will be attacked more. We will protect it,” he said.

Last week, the deputy chief of the Russian armed forces’ general staff said Russia’s “main tasks” of the invasion of Ukraine were complete.

“The combat capabilities of the Ukrainian armed forces have been substantially reduced, which allows us to concentrate our main efforts on achieving the main goal — the liberation of Donbas,” Colonel General Sergei Rudskoi said.

Last week, however, a senior U.S. Defense official said Ukrainians still have more than 90% of their combat power, in part because the U.S. and other allies have replenished them “in real time.”

Peace talks

Ukrainian President Volodymyr Zelenskyy said his country’s “sovereignty and territorial integrity” are a priority as Ukraine and Russia head into a new round of peace talks.

“We are looking for peace, really, without delay,” Zelenskyy said in a video address late Sunday. “There is an opportunity and a need for a face-to-face meeting in Turkey. This is not bad. Let’s see the outcome.”

Earlier Sunday, in a call with Russian journalists, Zelenskyy said Ukraine was open to adopting neutral status as part of a peace deal if it came with third-party guarantees and was put to a referendum.

Turkey is set to host the latest talks. Turkish President Recep Tayyip Erdogan said Monday that he would meet briefly with both the Russian and Ukrainian delegations ahead of the talks on Tuesday.

Speaking about the peace talks, Ukrainian Foreign Minister Dmytro Kuleba said on national television Monday that “the minimum program will be humanitarian questions, and the maximum program is reaching an agreement on a cease-fire.”

“We are not trading people, land or sovereignty,” he added.

The United Nations says the Russian invasion of Ukraine has pushed 10 million people out of their homes, and more than 3.8 million have fled the country.

In response to the invasion, the NATO alliance has increased defenses on its eastern flank, announcing four new battlegroups to Bulgaria, Hungary, Romania and Slovakia last week. Individual NATO members have also unilaterally sent troops and equipment to allied countries including Poland and the Baltic states, which neighbor Russia and have hosted NATO battlegroups since 2017.

Pentagon press secretary John Kirby announced that six U.S. Navy EA-18G Growler aircraft and about 250 air crew would arrive in Germany on Monday to bolster NATO’s defenses.

“These Growlers … specialize in conducting electronic warfare missions, using a suite of jamming sensors to confuse enemy radars,” Kirby told reporters.

“They are there to reinforce deterrence capabilities of the alliance on the eastern flank. They’re not there to engage Russian assets. That is not the goal,” the senior U.S. Defense official added.

Source: Voice of America

Qatar Fund for Development and Bill & Melinda Gates Foundation Jointly Pledge up to US$200 Million in New Partnership to Help Smallholder Farmers Adapt to Climate Change

Qatar Fund for Development (QFFD) and the Bill & Melinda Gates Foundation announced today, at the 2022 Doha Forum, a new strategic partnership called Nanmo, or “growing together” in Arabic. Nanmo will invest in climate-adaptive agricultural tools and technologies to build resilient food systems and markets that provide nutrition, income, and economic opportunities to small-scale producers and their communities across the African continent.

QFFD and the Gates Foundation jointly pledged up to US$200 million toward agriculture, climate resilience, and economic development projects to support smallholder farmers on drylands on the African continent. These farmers are bearing the brunt of the effects of climate change and this partnership will aim to strengthen economies in sub-Saharan Africa in four key areas:

• Equity as a primary driver of inclusive growth

• Enterprise as a means of job creation and poverty alleviation

• Agriculture as a primary source of food, jobs, and income

• Access to technologies, financial tools, and emerging best practices as a driver of productivity, nutrition, and climate adaptation

The partnership will also seek to ensure that women small-scale producers can positively contribute to, and benefit from, decisions about how their communities grow food and create jobs.

“Hundreds of millions of smallholder farmers, especially in sub-Saharan Africa, are already seeing their livelihoods threatened by higher temperatures and changing weather patterns,” said Bill Gates. “We’re building on our longstanding collaboration with QFFD to help these farmers adapt. Together, we can prevent millions of people from falling into poverty and hunger due to climate change and increase agricultural yields to jumpstart equitable economic growth where it’s most needed.”

The strategic partnership was announced by Bill Gates and Mr. Khalifa Al-Kuwari, Director General of QFFD, in the presence of Gates Foundation CEO Mark Suzman during a panel at the Doha Forum. It will support climate-adaptive tools, practices, policies, and markets as sustainable drivers of resilient food systems that provide nutrition, income, and economic opportunities to small-scale producers and their communities. It will also include systems-level research and country-level implementation to adapt to local environments.

One of the first projects funded by Nanmo will focus on improving the livelihoods of low-income women farmers in a number of African countries, working with the World Poultry Foundation to provide them with improved breeds of chicken for egg and meat production.

Mr. Khalifa Al-Kuwari said, “We are thrilled to be announcing a new initiative in collaboration with our strategic partner, the Bill & Melinda Gates Foundation, titled Nanmo, which aims at ensuring that sustainable development goals are met everywhere.” He added, “We have high hope that these valuable partnerships will expand our efforts to improve the lives of vulnerable communities, ensuring their economic security against the backdrop of this ever-evolving planet.”

The partnership will also fund projects with a clear path to achieving impact across multiple United Nations Sustainable Development Goals (SDGs), including poverty alleviation, agricultural transformation, nutrition, and youth and women’s and youth economic empowerment. Investments like these are especially important at a time when conflict in one part of the world can threaten food security across the globe.

“A thriving agriculture sector generates economic growth, but that growth doesn’t automatically benefit everyone equally,” said Melinda French Gates, co-chair of the Gates Foundation. “Nanmo isn’t just about protecting agriculture against climate change. It’s also about making sure that smallholder farmers, including millions of women, can lift themselves out of poverty and invest in a better future for their families and their communities.”

The Gates Foundation has spent over US$5 billion since 2009 on advancing agricultural development to support the needs of smallholder farmers in sub-Saharan Africa and South Asia. Stronger food systems for smallholder farmers are urgently needed to avert more serious hunger crises in dryland regions. This will help boost economies and improve the ability of farmers to respond and adapt to climate change.

About Qatar Fund for Development

QFFD is a Qatari public institution committed, on behalf of the State of Qatar, to implement foreign aid projects by international best practices and standards.

Since 2012, QFFD has been providing aid to many countries in accordance with the international cooperation goals of Qatar National Vision 2030. Its primary goal is to achieve inclusive and sustainable development by addressing global priority issues in education, health, and economic development. In this context, priority is given to the following Sustainable Development Goals:

• SDG 3: “Ensuring healthy lives and well-being for all”;

• SDG 4: “Ensuring fair and inclusive education for all and enhancing lifelong learning for all”;

• SDG 8: “Promoting sustained, inclusive and sustainable economic growth and keeping full and productive employment and decent work for all.”

To realize optimal development impact, QFFD projects are also designed to have cross-cutting co-benefits within SDG 2 “Zero hunger” and SDG 6 “Ensuring availability and sustainable management of clean water and sanitation for all,” in addition to SDG 17 “Partnerships to achieve goals.”

QFFD cooperates with many reputable actors through strategic partnerships both locally and internationally. These include Civil Society Organizations, government agencies, UN agencies, and the private sector.

About the Bill & Melinda Gates Foundation

Guided by the belief that every life has equal value, the Bill & Melinda Gates Foundation works to help all people lead healthy, productive lives. In developing countries, it focuses on improving people’s health and giving them the chance to lift themselves out of hunger and extreme poverty. In the United States, it seeks to ensure that all people—especially those with the fewest resources—have access to the opportunities they need to succeed in school and life. Based in Seattle, Washington, the foundation is led by CEO Mark Suzman, under the direction of Co-chairs Bill Gates and Melinda French Gates and the board of trustees.

Source: Qatar Fund for Development